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imikhiqizo

I-Exemestane / I-Aromasin Cancer Treatment I-Anti Estrogen Steroids Yokusika / Ukuqoqa Umjikelezo

Incazelo emfushane:


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Imininingwane Esheshayo

I-Exemestane

Isibizo: Aromasin;I-Exemestan

Ukubukeka: I-Crystalline Powder Emhlophe noma Cishe Emhlophe

Okuqukethwe komkhiqizo: ≥ 99%CAS:107868-30-4

Ifomula yemolekyuli: C20H24O2

Isisindo se-molecule: 296.40

1

Sebenzisa: isetshenziswa ekwelapheni umdlavuza webele we-metastatic.futhi isetshenziswe njengosizo ekwelapheni umdlavuza webele wakuqala.

Ungase futhi uyizwe ibizwa nge-Aromasin, okuyigama layo lomkhiqizo elaziwa kakhulu.Kunenombolo yezinye izinhlobo ze-exemestane, zonke eziqukethe umthamo ofanayo womuthi.

Amathiphu Omthamo

Umthamo Ojwayelekile Wabantu Abadala Womdlavuza Webele:

25 mg ngomlomo kanye ngosuku

Amazwana:

- Lesi sidakamizwa kufanele sinikezwe ngemuva kokudla.

Isebenzisa:

- Ukwelashwa kwe-adjuvant kwabesifazane abangemva kokuya esikhathini abanomdlavuza webele wangaphambi kwesikhathi we-estrogen-receptor abathole iminyaka emibili kuya kwemithathu ye-tamoxifen futhi bashintshelwa ku-exemestane ukuze kuqedwe ingqikithi yeminyaka emihlanu elandelanayo yokwelashwa kwe-adjuvant hormone.

- Ukwelashwa komdlavuza webele othuthukisiwe kwabesifazane abangemva kokuya esikhathini abanesifo esithuthukile kulandela ukwelashwa kwe-tamoxifen.

Incazelo

I-Aromasin (i-Exemestane acetate) ingenye yalezo zinhlanganisela eziyinqaba okungekho muntu owazi ngempela ukuthi enzeni ngazo.Isizukulwane sesithathu i-Aromatase Inhibitor (AI) njenge-Arimidex (Anastrozole) ne-Femera (Letrozole).

isizukulwane sesithathu i-aromatase inhibitors, esetshenziswa ekwelapheni umdlavuza webele we-metastatic futhi isetshenziswa njengosizo ekwelapheni umdlavuza webele wakuqala.

● I-Aromasin ingenye yezinhlanganisela ezinamandla kakhulu zokucindezela i-estrogen.

● I-Aromasin ingenye yezinhlanganisela ezingcono kakhulu zokwehlisa umphumela onuka kamnandi wama-steroid.

● I-Aromasin iyatholakala kubakhi bomzimba abathatha ama-anabolic steroids.

● I-Aromasin yaziwa nangokuthi i-Exemestane.

● Isebenza ngokuvimbela i-enzyme i-aromatase, kamuva ivimbele ukukhiqizwa kwe-estrogen.

● I-Aromasin iphinde ibe uhlobo lwe-.antineoplastic (hormonal) izinto zokusetshenziswa.

I-Aromasin isetshenziselwa ukulwa nomdlavuza webele futhi ikhulise i-testosterone emzimbeni.

I-Exemestane ivimba inqubo ye-aromatisation.Ngakho-ke yehlisa inani le-estrogen emzimbeni.Ekuqaleni komdlavuza webele, ukuthatha i-exemestane kungasiza ukumisa umdlavuza webele ukubuya.Kumdlavuza webele osuthuthukile amangqamuzana omdlavuza angase akhule kancane kancane noma ayeke ukukhula ngokuphelele.

I-Exemestane iyi-aromatase inhibitor.Lokhu kusho ukuthi ivimba i-enzyme i-aromatase (etholakala emisipha yomzimba, esikhunjeni, emabeleni nasemafutheni), esetshenziselwa ukuguqula ama-androgens (amahomoni akhiqizwa izindlala ze-adrenal) abe yi-estrogen.Uma i-estrogen ingekho, izimila ezincike kule hormone ukuze zikhule zizoncipha

Izinzuzo ze-Exemestane

>>.Ukwakha umzimba

I-Steroidal Exemestane inhibitor eyenza ngokunciphisa inani le-estrogen ekhiqizwa umzimba.Isebenza ngokunciphisa ukuguqulwa kwe-Testosterone ku-estrogen futhi izinga elijwayelekile lokucindezelwa kwe-estrogen yi-85%.Umuthi ubuye wehlise amazinga e-estradiol angaba ngu-50%, kanye nokwandisa kakhulu amazinga e-testosterone.

I-Exemestane inhibitor esebenza ngokuvimbela ukuhlanganiswa kwe-estrogen.Isebenza ngempumelelo ekwandiseni amazinga e-Testosterone ne-IGF emzimbeni.Umuthi futhi uwusizo kakhulu phakathi nombuso wokwelashwa komjikelezo wokuthunyelwe lapho umuntu ezama ukubuyisela amazinga emvelo we-Testosterone ukuze agweme ukuphahlazeka komjikelezo wokuthunyelwe.

>>.Anti-estrogen umuthi

Njengoba yaziwa njengenye yezidakamizwa ezibiza kakhulu, i-Exemestane ingenye yezidakamizwa ezilwa ne-estrogen eziphephile ezisetshenziswa kakhulu abasubathi nabakhi bomzimba.Ngokwemithi umuthi umiselwe ikakhulukazi ukwelapha umdlavuza webele.Evame ukubizwa ngokuthi i-Selective Estrogen Receptor Modulator (SERM), yayisetshenziselwa ukuvimbela i-gynocomastia.

Umsebenzi we-Exemestane

A)I-Exemestane yokuvimbela umdlavuza webele:

I-Chemoprevention yomdlavuza webele iyindlela ephumelelayo yokunciphisa ukutholakala kwalesi sifo kwabesifazane abasengozini.Ama-ejenti okuqala abonisa umphumela obalulekile we-chemopreventive kwakuyi-SERMs tamoxifen ne-raloxifen.

Ukuhlaziywa okuphelele okubuyekeziwe kwazo zonke izivivinyo zokuvimbela i-SERM kubonise ukuthi ziyakwazi ukunciphisa izehlakalo zomdlavuza webele kwabesifazane abasengozini enkulu kanye nesilinganiso, umphumela osekelwa ukuncipha komdlavuza webele ohlaselayo we-ER-positive.

B)I-Exemestane iyisivimbeli se-steroidal esingahlehliseki sesizukulwane sesithathu se-enzyme ye-aromatase futhi sisebenza kahle kuzo zonke izilungiselelo zokwelapha umdlavuza webele, okuhlanganisa ne-chemoprevention.

Esimeni se-metastatic, i-exemestane iye yaphenywa kabanzi njengokwelashwa komugqa wokuqala, umugqa wesibili, kanye nomugqa owengeziwe futhi manje isibhaliselwe ukwelashwa kwabesifazane abadlule kokuya esikhathini abanomdlavuza webele we-hormone-receptor-positive othuthuke kakhulu isifo sabo siqhubekele phambili kulandela i-antiestrogen. ukwelashwa.

Qaphela, ukuntuleka okungenzeka kokuphikiswa okuphambene nama-NSAI kuveza amathuba engeziwe ekulandeleni ukwelashwa kwama-ejenti we-endocrine.Ngaphezu kwalokho, ngokusekelwe emiphumeleni enengqondo yomtholampilo, i-exemestane ne-everolimus imelela inketho yokwelapha ephumelelayo yesifo esiye sathuthuka ngemva kokuchayeka kuma-NSAI.

I-Exemestane ngokuvamile ibekezelelwa kahle, inephrofayili yomphumela ofanayo efana neyamanye ama-AI futhi okuhlanganisa izimpawu zokunqamuka kokuya esikhathini, i-arthralgia, ukulahlekelwa kwamathambo, nokuguqulwa kwe-lipid metabolism.


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