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Izindaba

Ubuchwepheshe obusha

1) i-biotechnology: ubuchwepheshe bobunjiniyela bezakhi zofuzo, ubuchwepheshe obusebenzayo be-biotransformation, ubuchwepheshe be-enzyme catalysis yezimboni

I-2) I-Green Chemistry: ukusabela kwe-stereoselective, isisombululo esiluhlaza se-reagent, inqubo yokuqinisa ubuchwepheshe

Izinga lokushisa lokusabela: – 100 ℃ ~ 150 ℃

Ingcindezi yokusabela kwe-Hydrogenation: ingcindezi yasemkhathini ~ 5 MPa

Izinhlobo zokusabela: Ukusabela kwe-Grignard, ukusabela kwe-hydrogenation, ukusabela okukhethiwe kwe-redox, ukusabela kokuhlela kabusha, ukusabela kwe-witting, ukusabela kwe-fluorination, ukusabela kwe-Foucault, ukusabela kwe-enzyme catalyzed, njll.

Ikakhulukazi, sinolwazi olucebile, isizinda sobuchwepheshe kanye nekhono eliqinile lobunjiniyela nokukhulisa isixhumanisi ekuhlolweni komzila wokwenziwa, ukuthuthukiswa kwenqubo yokuthuthukisa, ukukhuliswa kwenqubo kanye nokusetshenziswa.

Umphumela: Thuthukisa ukusebenza kahle, unciphise izindleko, futhi uguqule isimo esibucayi sokungcoliswa kwemvelo nokusetshenziswa okuphezulu kwamandla.

Inqubo Yokukhiqiza Yezinhlanganisela Ze-steroidal

Izindlela ezivamile ukuhlanganiswa kwamakhemikhali kanye nokuguqulwa kwe-microbial, lapho ukuguqulwa kwe-microbial kudlala indima ebalulekile kuyo yonke inqubo yokukhiqiza.Umkhawulo omkhulu wendlela yokuhlanganisa amakhemikhali esetshenziswa kwinhlanganisela ye-stereochemical usekukhetheni kwayo okungalungile.Ukucaciswa okuphezulu kokusabela kwe-enzymatic okubangelwa ama-enzyme ebhayoloji kungakha ukuntuleka kwe-Chemical Synthesis.Ukwethulwa kwama-enzyme ku-steroids kuguqulwe kwaba imodeli efanelekile.

I-microbial enzymatic catalysis ukuguqulwa kwengxenye ethile (noma iqembu) yenhlanganisela yezinto eziphilayo ibe enye inhlanganisela efana nesakhiwo.Umkhiqizo wokugcina wokuguqulwa awukhiqizwa ngochungechunge lwezinqubo ze-metabolic zamangqamuzana amancane, kodwa wakhiwa ukusabela kwamakhemikhali kwengxenye ethile ye-substrate kusetshenziswa uhlelo lwe-enzyme lwamangqamuzana amancane.Ukusabela kwe-microbial transformation kuma-steroids kuhlukene, futhi anamandla okuguqula ama-athomu noma amaqembu kuzo zonke izindawo ze-steroids, kuhlanganise ne-nucleus yomzali namaketanga aseceleni, kukhona i-oxidation, ukunciphisa, i-hydrolysis, i-esterification, i-acylation, i-isomerization, i-halogenation, ukuvulwa kwendandatho, ukuwohloka kweketango elisemaceleni.Ngezinye izikhathi i-microbe ingase iphinde ibhekane nokusabela okuhlukahlukene okuhlukahlukene ku-steroid ngesikhathi esisodwa.I-Hydroxylation ingenye yezindlela ezibaluleke kakhulu zokusabela ekuguqulweni kwe-microbial of steroids.Ama-microorganisms angakwazi ukwenza i-hydroxylation reaction kunoma iyiphi indawo ye-steroids, kodwa indlela yamakhemikhali inzima ukwethula i-hydroxyl kwezinye izindawo ngaphandle kwe-C-17.Ukuhlanganiswa kwamakhemikhali kanye nokuguqulwa kwe-microbial kuyinqubo yokukhiqiza ephumelelayo, ekhuthaza kakhulu ukukhiqizwa kwezimboni kwezidakamizwa ze-steroid.

Izinzuzo Zobuchwepheshe

1) Uhlelo oluphelele lokuvutshelwa

2) Ukubona ukusetshenziswa kobuchwepheshe obuhlukahlukene be-chemical sybthesis

3) Ukwakhiwa nokusetshenziswa kwe-enzyme

4) Inhlanganisela ephelele yokuguqulwa okuhlukile


Isikhathi sokuthumela: Jul-08-2021