I-Dutasteride imakethwa ngokwemithi njenge-Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost.Ngezizathu ezingaziwa, izivivinyo zokuqala zomtholampilo ze-dutasteride zanqanyulwa kungazelelwe ngo-2002, zase ziqhubeka kamuva.

I-Dutasteride iyi-5-alpha-reductase inhibitor, okusho ukuthi ivimbela isenzo se-5a-reducatse enzymes, enesibopho sokunciphisa i-5a (ukuguqula) i-testosterone ibe yi-dihydrotestosterone (DHT) ngokungezwa kwe-hydrogen bond kabili.

I-Dutasteride ivimbela kokubili ama-isoforms we-5a-reductase, ngakho-ke ivimbela ukuguqulwa kwe-testosterone ku-dihydrotestosterone.Lokhu kwenza i-Dutasteride ibe ukwelashwa okufanele kwe-Male Pattern Baldness.Yiqiniso, uma uguqula i-Testosterone encane ku-Dihydrotestosterone, ukhulisa amazinga e-testosterone ngokuzenzakalelayo (ukuguqulwa okuncane).

I-Dutasteride, ku-2.5mgs/ngosuku cishe i-1.5x isebenza kangcono kune-Finasteride ku-5mgs/ngosuku, ekwelapheni ukulahleka kwezinwele (kokubili ukukumisa kanye nokuzikhulisa kabusha).Ukwengeza, i-Dutasteride ingasetshenziswa ngempumelelo kulowo mthamo ofanayo ukuze uphathe ukwanda kwe-prostate, futhi umphumela owaziwa kancane we-Dutasteride (futhi, kulowo mthamo ofanayo) ukusetshenziswa ukwelapha i-Acne ebangelwa ukuchichima kwe-androgens emzimbeni.

Ukuze i-steroid isebenzisa umsubathi ohlushwa yimiphumela emibi ehlobene ne-DHT, i-Dutasteride ingaba yimpendulo.Ukuqothuka kwezinwele, Izinduna, nokukhula kwendlala yesinye (okungenzeka) kungamiswa ngokuphelele ngokusetshenziswa kwalo mkhiqizo.Ngeshwa, i-DHT akuyona yonke into embi, futhi ungahle ulahlekelwe ubulukhuni bemisipha (ikhwalithi ye-amorphous uma ikhona), ngisho nezinye izimfanelo esizithandayo ekusebenziseni kwethu i-androgen.

Futhi…njengoba lokhu kuvimbela kuphela ukuncishiswa kwe-5a kwama-androgens angaphansi kwalokho kuguqulwa abe uhlobo lwe-dihydro yawo…cishe ngeke kwenze lutho ukumisa ukuqothuka kwezinwele noma ezinye izimpawu ezibangelwa ngokuphelele ukusetshenziswa kwama-androgens emndenini we-DHT.

I-Dutasteride, kanye ne-Finasteride iyi-5-alpha-Reductase inhibitor okuyiqembu lezidakamizwa ezine-anti-androgenic properties ezivimbela ukuguqulwa kwe-testosterone ku-dihydrotestosterone (DHT).Leli yikhemikhali efanayo etholakala ku-Proscar kanye ne-Propecia futhi isetshenziswa ekwelapheni i-hyperplasia kanye ne-androgenic alopecia.Ngenxa yokuthi le mithi inciphisa amazinga e-dihydrotestosterone (DHT) isetshenziselwa ukuvimbela nokwelapha ukuqothuka kwezinwele.Isetshenziswa kakhulu ekwelapheni i-prostate glands ekhulisiwe.